what causes peeling skin syndrome

All rights reserved. But in some cases complicationsmay include: Call the healthcare provider right away if your child has red, blistering skin. Privacy Policy|Advertising Policy|Privacy Preferences Center|Do Not Sell My Personal Information. AskMayoExpert. AskMayoExpert. Mayo Clinic; 2021. Treatment includes antibiotic medicine, replacing fluids, and skin care. Neonatal desquamation (child). It may also be a sign of an immune system disorder or other disease. - Cutaneous T-cell lymphoma. The content on Healthgrades does not provide medical advice. Staphylococcal scalded skin syndrome is a complication of a staphylococcal skin infection in which the skin blisters and peels off as though burned. Learn more about what causes it, associated symptoms, and more. The infection causes peeling skin over large parts of the body. Peeling skin syndrome 1. Then the use of cleansers / soap in the genital area also has the potential to cause allergies or irritation. The presence of systemic symptoms should point away from the diagnosis of PSS. VITAMIN E. Tinea capitis. Causes. AskMayoExpert. This content is not available in your current region. Treatment may include: Children who are treated right away usually recover with no scarring or other problems. Hospitalized treatment includes stopping the problem medication, replacing electrolytes, applying skin dressings, and providing pain medications and antibiotics. Know why a new medicine or treatment is prescribed and how it will help your child. More often, many people end up with dry, cracked skin due to deficiency of certain B vitamins. AskMayoExpert. Tinea Pedis. The genes that cause peeling skin syndrome due to their malfunctioning are TGM5, CHST8, FLG2, CSTA, SERPINB8, and CDSN. Stevens-Johnson syndrome causes only small areas of peeling skin (affecting less than 10% of the body). According to drugs.com, Lamictal skin peeling could require hospitalization and could lead to Stevens Johnson Syndrome. AskMayoExpert. This gene localizes to the human epidermis and other epithelia. Invasive staph infections can be life threatening if not treated immediately. The peeling is usually present from birth, but can appear later in childhood or early adulthood. In this case, it attacks the glands that produce moisture. It can occur at any age, but children under 5 years of age are at highest risk. What Does Refresh Share Attachment Mean On Facebook? The term "acral" refers to the fact that the skin peeling in this condition is most apparent on the hands and feet. TGM5 signals the body to create the TGM5 enzyme that is found in the tissues including the epidermis. This condition is very rare, and. Acral peeling skin syndrome is linked with mutations in gene transglutaminase 5 (TGM5) and less commonly with mutations in gene cystatin A (CSTA). https://medlineplus.gov/genetics/condition/acral-peeling-skin-syndrome/. Some people have trouble walking. It may also be a sign of an immune system disorder or other disease. Desmosomes are the parts of the skin cell that are responsible for adhering . Peeling skin may occur because of direct damage to the skin, such as from sunburn or infection. View a slideshow to see photos of peeling skin syndrome and other uncommon skin conditions. It most commonly causes painless peeling of the top layers of skin on your hands and feet. The Latest Innovations That Are Driving The Vehicle Industry Forward, Tinea infections (Athletes foot, jock itch, ringworm). Lab findings are within normal limits in patients with isolated PSS. Immerse a washcloth in milk. Health Conditions This bacterium produces an exfoliative toxin that causes the peeling of the skin over large parts of the body. 8 How is Stevens Johnson syndrome related to skin peeling? Learn more: Vaccines, Boosters & Additional Doses | Testing | Patient Care | Visitor Guidelines | Coronavirus | Email Alerts. Itchiness or pruritus Rashes Redness (erythema) Dehydration Scaling of the skin Skin fissures or cracking Skin tightness after bathing Skin inflammation Extreme sensitivity to external irritants such as heat, sweat, or water Medical Treatment for Peeling Skin The treatment for peeling skin aims to address its underlying cause. Mayo Clinic does not endorse any of the third party products and services advertised. Dryness may be one of the most common explanations for peeling feet. What virus causes skin peeling? Original article: https://www.mayoclinic.org/symptoms/peeling-skin/basics/causes/sym-20050672. Drug eruption. Causes. Although this disease primarily affects children, it also can occur in adults. Rash, itching, dryness and other irritating skin problems may accompany peeling skin. It most commonly causes painless peeling of the top layers of skin on your hands and feet. MedlinePlus. It's more common in the summer and fall. Your arms and. A dermatologist can determine the cause and suggest an appropriate treatment. A staph-infected wound is likely to be tender and swollen, with evidence of pus. You may have trouble buttoning your clothing. If you have peeling skin, it's a sign that your skin is healing from some type of damage. Rash, itching, dryness and other irritating skin problems may accompany peeling skin. AskMayoExpert. Onset of symptoms is usually rapid. Some types of medications, such as topical retinoids used for acne, can cause . Accessed April 5, 2022. Know what to expect if your child does not take the medicine or have the test or procedure. Kawasaki Disease Although less likely, Kawasaki disease -- a possible autoimmune disorder -- might cause your painful joints and peeling skin 2 . - Jock itch. Kawasaki disease (child). Staphylococcal scalded skin syndrome is an illness characterized by red blistering skin that resembles a burn or scald, hence the name. Medical conditions such as Reiter's syndrome or endrocrinal problems may also lead to peeling of skin on feet. In most cases, using OTC medications can help treat the peeling on your feet. Few major problems that lead to peeling skin on hands and feet include toxic shock syndrome, dermatitis developed by too much dandruff, ringworm, psoriasis, Kawasaki disease, fungal infections, eczema, athlete's foot, toxic epidermal necrolysis, peeling skin syndrome, few specific types of cancers, immune system disorders, skin infections . Mayo Clinic; 2021. Find more COVID-19 testing locations on Maryland.gov. AskMayoExpert. Eczema. It most commonly causes painless peeling of the top layers of skin on your hands and feet. As noted in a 2019 case letter, acral peeling skin syndrome was first reported in 1921 by Dr. Howard Fox. It is when the child inherits the defective copy of the gene from both the parents that peeling skin syndrome surfaces. Health Conditions As noted in a 2019 case letter, acral peeling skin syndrome was first reported in What Does Archiving A Group On Facebook Mean? Most forms of PSS manifest at birth or during infancy with shedding or peeling of the outermost layer of the skin (horny layer, aka stratum corneum). 7 When does peeling skin syndrome ( PSS ) occur? You can pick up this fungus in damp areas like showers. The first sign of keratolysis exfoliativa is one or more superficial air-filled blisters on the fingers or palms. The cells die and shed too quickly in a process called turning over. Other risk factors include: Weak immune system Xerosis (dry skin). - Athlete's foot. Peeling skin syndrome 1 is caused by a genetic defect in the corneodesmosin (CDSN) gene. Some people with PSS have itching, redness, and scarring. Acral peeling skin syndrome is a very rare genetic condition that causes peeling of the skin on your hands and feet. Peeling skin may occur because of direct damage to the skin, such as from sunburn or infection. - Add a Humidifier. - Use a Gentle Exfoliant Occasionally. What causes skin to peel excessively? The FDA and certain drug warning sites point out the correlation. Conditions that may cause skin peeling include: Allergic reactions Infections, including some types of staph and fungal infections Immune system disorders Cancer and cancer treatment Genetic disease, including a rare skin disorder called acral peeling skin syndrome that causes painless peeling of . Your skin is regularly exposed to environmental elements that can irritate and damage it. Some conditions that cause peeling of the skin on hands and feet in children include: Kawasaki Syndrome Psoriasis Dermatitis Lichen Planus Pink Disease Steven Johnsons Syndrome Environmental Causes Apart from the genetic defects, environmental factors also play a role in worsening skin peeling on the feet and toes. Hello Lala. Help Millions of people find the right doctor and care they need, Get immediate care and visit with providers from the comfort of your home, or anywhere, Urgent care centers can be faster and cheaper for situations that are not life threatening, Doctors and patients discuss the latest medical treatments and health tips, Search prescription drugs for why theyre used, side effects and more, Back and Neck Surgery (Except Spinal Fusion). Peeling skin may occur because of direct damage to the skin, such as from sunburn or infection. Causes of peeling nipple. Other findings may include blistering and/or reddening of the skin (erythema) and itching (pruritus). Acral peeling skin syndrome is caused by mutations in the TGM5 gene. Read on to learn whether it poses risks. Staphylococcal scalded skin syndrome: This infectious disease is caused by various strains of the Staphylococcus aureus bacteria and can cause the skin to peel. In children,the disease usually begins with fussiness (irritability), tiredness (malaise), anda fever. Call your health care provider if you have any doubt about the cause of peeling skin or if the condition is severe. Peeling skin syndrome (PSS) refers to a group of conditions that causes skin to peel and tear easily. Staphylococcal scalded skin syndrome is caused by toxins produced by certain strains (most commonly phage group 2 strains 55 and 71) of the bacterial germ Staphylococcus aureus. The healthcare provider will ask about your childs symptoms and medical history. Sunburn. Learn more about the symptoms and treatment options here. Is there a cure for peeling skin syndrome? Genetic mutations in the TGM5 or CSTA genes are implicated in acral peeling skin syndrome, while of the 2 generalized variants, only the type B, inflammatory generalized type, has been associated with a homozygous non-sense mutation in the CSDN gene (which encodes corneodesmosin) [ 9, 15, 16 ]. - Hyperhidrosis. - Contact dermatitis. Peeling skin (desquamation) occurs when the top layer of your skin peels to replace itself. Rash, itching, dryness and other irritating skin problems may accompany peeling skin. https://www.merckmanuals.com/professional/dermatologic-disorders/dermatitis/erythroderma. The rapid turnover of skin cells causes significant peeling and scaling of the skin. Take off the cloth after 10 minutes and, subsequently, rinse off the area. The various syndromes include peeling skin syndrome 1, 2, 3, 4, 5, and 6. can cause superficial skin peeling. If the healthcare provider is not available, go to the emergency room. Mayo Clinic; 2021. Accessed April 5, 2022. The skin peeling involves the entire top layer of the skin (the epidermis), which sometimes peels off in sheets from large areas of the body (see Structure and Function of the Skin ). Peeling skin syndrome (PSS) is a group of rare inherited skin disorders in which the normal gradual process of invisible shedding of the outermost skin layers is hastened and/or aggravated. It's usually caused by an infection with a type of Staphylococcal aureas bacteria. What causes generalized inflammatory peeling skin syndrome ( Netherton )? In addition to the blistered, peeling skin, the person has fever, chills, and weakness. Mayo Clinic; 2021. Place and press the cloth over the peeled skin. Mayo Clinic; 2022. Mayo Clinic; 2022. Which children are at risk for SSSS? Peeling skin can also be a symptom of veiled health condition that we can't diagnose at home. AskMayoExpert. This gene provides instructions for making an enzyme called transglutaminase 5, which is a component of the outer layer of skin (the epidermis). The cause of peeling cuticles may involve anything to do with environmental elements including wind, heat, excessive humidity or allergens and irritants. AskMayoExpert. Exposing the skin to cold winds and other environmental irritants, burns, etc. Does staph infection cause skin peeling? Psoriasis. Peeling skin caused by dry skin or mild sunburn is likely to improve with nonprescription lotions and doesn't require medical care. Does staph infection cause skin peeling? The blisters burst to leave expanding collarettes of scale and circular or oval, tender, erythematous peeled areas. PSS is characterized by painless, continual, spontaneous skin peeling (exfoliation) due to a separation of the outermost layer of the epidermis (stratum corneum) from the underlying layers. Other unknown genes may also play a part in the development of this skin condition. It looks like the skin has been scalded or burned by hot liquid. 2. - Atopic dermatitis (eczema) (Ritter Disease) Staphylococcal scalded skin syndrome is a complication of a staphylococcal skin infection in which the skin blisters and peels off as though burned. The main symptom is continual peeling of the skin. Staphylococcal scalded skin syndrome (SSSS)is a serious skin infection. Also know what the side effects are. Skin peeling occurs spontaneous, is painless, and may persist lifelong with gradual improvements. It is one of the best soothing remedies for peeling skin. If you continue to use this site we will assume that you are happy with it. What causes peeling skin syndrome Acral peeling skin syndrome is caused by mutations in the TGM5 gene. What infections cause peeling skin on hands? This means that the bodys own immune system attacks its own cells and tissues by mistake. In babies born past their due date, it's not unusual for them to experience some painless skin peeling. Peeling can be produced by rubbing skin specially if presoaked in water. Tips to help you get the most from a visit to your childs healthcare provider: At Another Johns Hopkins Member Hospital: CHG Bathing to Prevent HealthcareAssociated Infections, Masks are required inside all of our care facilities, COVID-19 testing locations on Maryland.gov, General Pediatrics and Adolescent Medicine, Long-term (chronic) kidney disease or kidney failure, Fluid-filled blisters thatbreakeasily and leave an area of moist skin that soon becomes tender and painful, Large sheets of the top layer of skin may peel away, Your childs age, overall health, and medical history, How well your child handles certain medicines, treatments, or therapies, If your childs condition is expected to get worse, The opinion of thehealthcare providersinvolved in your child's care, Antibiotic medicine given by IV (intravenous) line into the vein, Feedings through a tube from the mouth into the stomach (nasogastric feeding), if needed, Use of skin creams or ointments and bandages, Loss of fluid causing dehydrationand shock like a burn patient, Staphylococcal scalded skin syndromeis usually from a bacterialinfection. - Apply Moisturizer. What Causes Acral Peeling Skin Syndrome? It can occur at any age, but children under 5 years of age are at highest risk. https://www.merckmanuals.com/professional/infectious-diseases/gram-positive-cocci/toxic-shock-syndrome-tss?query=toxic%20shock%20syndrome#. Non-IgE-mediated drug sensitivity. Before your visit, write down questions you want answered. Get evaluated by a dermatologist MILK. The skin becomes dry and flaky and hair may turn dry, dull and straw like in appearance. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. PSS type A is characterized by noninflammatory and asymptomatic peeling. This is followed byredness of the skin. 4 What immune system causes peeling skin? Athlete's foot is a fungal infection of the feet. There are many reasons why your feet can peel. Three types of PSS have been characterized based on the areas of skin affected, presence of systemic manifestations, and distinct genetic mutations. Peeling skin syndromes (PSSs) are a heterogeneous group of rare, autosomal recessive disorders characterized by superficial, painless peeling and blistering of the skin without mucosal fragility [].The two major forms are acral peeling skin syndrome (APSS; also called localized PSS) and generalized PSS [].The latter is subclassified into noninflammatory (type A) and inflammatory . Rash, itching, dryness and other irritating skin problems may accompany peeling skin. Peeling skin syndrome is a rare genodermatosis with variable age of onset from birth to adulthood. B vitamins such as niacin (B3) and biotin (vitamin B7) are extra important for healthy skin, says Bank. sebaceous hyperplasia. Skin peeling is the hallmark of these conditions. Treatment usually requires a hospital stay, often in the burn or intensive care unit of the hospital. Sunburns, allergies and skin diseases cause skin to peel. The differential for PSS includes other causes of superficial desquamation of the skin. Here are some tips on caring for your skin if you have been diagnosed with Sjogren's syndrome. Superficial fungal infection. It may also be a sign of an immune system disorder or other disease. A number sign (#) is used with this entry because of evidence that peeling skin syndrome-6 (PSS6) is caused by homozygous mutation in the FLG2 gene ( 616284) on chromosome 1q21. The website stated that Stevens Johnson Syndrome affects between 0.3% to 0.8% in pediatric Lamictal patients and between 0.08% to 0.3% in adult Lamictal patients. Scalded skin syndrome, or SSS, is a serious skin condition that occurs as a reaction to a bacterial toxin. All Rights Reserved. Know the reason for the visit and what you want to happen. Know why a test or procedure is recommended and what the results could mean. Treatments for cancer, acne and aging can also cause peeling skin. 7,752,060 and 8,719,052. Know how you can contact your childs provider after office hours. Other risk factors include: Symptoms can occur a bit differently in each child. - Kawasaki disease. Athlete's Foot. Peeling skin syndrome (PSS) refers to a rare group of heterogeneous autosomal recessive diseases that manifest as superficial skin peeling without mucosal peeling. Invasive staph infections can be life threatening if not treated immediately. Ask if your childs condition can be treated in other ways. Psoriasis. Friction dermatosis. The two major forms are acral peeling skin syndrome (APSS; also called localized PSS) and generalized PSS [4-7]. Contact dermatitis. Learn what causes flaky skin shedding and how to stop skin peeling. Repeated irritation can lead to skin peeling. Copyright 2022 Healthgrades Marketplace, LLC, a Red Ventures Company, Patent US Nos. The affected skin can resemble a burn wound, giving the condition its name. He or she may be in the burn unit of the hospital. It may also be a sign of an immune system disorder or other disease. 14. Acral peeling skin syndrome can be caused by genetic changes in the TGM5 gene. It causes the outer layer of the skin to peel, blister, or both. In addition, there may be hair loss as well. It may also be a sign of an immune system disorder or other disease. Initially, it doesn't cause any pain or abnormality but gradually some air-filled blisters take over the skin of palms and/or soles. What Does LML Mean In Texting On Facebook? The release of two exotoxins (epidermolytic toxins A and B) from toxigenic strains of the bacteria Staphylococcus aureus causes SSSS. The peeling skin is usually painless. Seborrheic dermatitis. Use of this website and any information contained herein is governed by the Healthgrades User Agreement. Peeling Skin Syndrome 2 Peeling Skin Syndrome 2 is caused by a genetic defect in the TGM5 gene. Acral peeling skin syndrome. Accessed April 5, 2022. Peeling skin syndrome is a rare genetic disorder that causes skin to continuously peel. hands peeling after virusmetal arms: glitch in the system characters Masks are required inside all of our care facilities. PSS is accompanied by symptoms like reddening and itching of the skin. - Pat Skin Dry After Bathing. Merck Manual Professional Version. Picking at peeling skin can lead to infection. The skin may swell and become red due to inflammation. Acral peeling skin syndrome is a very rare genetic skin condition. It looks like the skin has been scalded or burned by hot liquid. It may be hard to pick up small things such as a pen or a fork. How is Stevens Johnson syndrome related to skin peeling? AskMayoExpert. The diagnosis is based on the appearance of the skin, but sometimes a biopsy is done. A staph-infected wound is likely to be tender and swollen, with evidence of pus. Peeling skin may arise from infectious diseases, such as: Scarlet fever Staphylococcal scalded skin syndrome Tinea infections (Athlete's foot, jock itch, ringworm) Toxic-shock syndrome (late) Other causes of peeling skin Various other causes of peeling skin include: Certain acne treatments, such as those containing retinol or benzoyl peroxide Always consult a medical provider for diagnosis and treatment. This is important if your child becomes ill and you have questions or need advice. Your child may also have tests, such as: Your child will likely need to be treated in the hospital. This gene provides instructions for making an enzyme called transglutaminase 5, which is a component of the outer layer of skin (the epidermis). Cause Skin infections generally occur in one of two ways 2. If your child has a follow-up appointment, write down the date, time, and purpose for that visit. Occasionally, peeling also occurs on the arms and legs. Organisms implicated in this involve candida and trichosporon. What Does Connect Mean On Facebook Messenger? Dry skin in Sjogren's syndrome can occur as a result of an autoimmune attack on the moisturizing and lubricating mechanisms of the skin, which involves hair, sweat glands, and oil glands. What does it mean if your skin is randomly peeling? Other considerable vitamin deficiencies include vitamins A and C. Symptoms that indicate vitamin deficiency widely vary with a vitamin type. Milk has certain properties that peel off the dead, dry skin. He or she will give your child a physical exam. Learn more about the possible causes of nipple flaking and how to treat it in the following FastlyHealarticle. Sjgren syndrome is an autoimmune disorder. Clinically, it is characterized by a pruritic or nonpruritic spontaneous superficial peeling of the skin, which sometimes is accompanied by erythema or vesiculation. AskMayoExpert. Here are some treatment methods and tips to stop the peeling once its started. Peeling and Flaky Skin If the skin on your fingertips is suddenly flaky, you may have a vitamin B deficiency. Acral peeling skin syndrome (APSS) is an inheritable skin condition that causes painless peeling of the top layer of skin, typically on the hands or feet. The skin peeling involves the entire top layer of the skin (the epidermis), which sometimes peels off in sheets from large areas of the body (see Structure and Function of the Skin ). Acral refers to the fact that the peeling is most apparent on the hands and feet, although peeling may also occur on the arms and legs. We are vaccinating all eligible patients. Causes of Peeling Feet Dryness. Children who get prompt treatment usually recover with no scarring or complications. The term peeling skin syndrome was given by Levy and Goldsmith in 1982. Asymptomatic shedding of large sheets of the skin, present since birth or early childhood, is a characteristic of PSS. 15. At the visit, write down the name of a new diagnosis, and any new medicines, treatments, or tests. Skip to main content Check Your. Toxic shock syndrome; Other causes of peeling skin: Various other causes of peeling skin include: Certain acne treatments, such as those containing retinol or benzoyl peroxide; Chemical peels or use of facial creams containing retinol to reduce aging; Harsh soaps and detergents can cause drying of the skin; Peeling skin syndrome (a rare genetic . The presence of abrasions in the genital area can be influenced by various causes, such as trauma due to friction, it can be due to masturbation, sexual intercourse, or because of scratching. Acral peeling skin syndrome is a rare genetic condition that causes the top layer of the skin to peel. Additional symptoms may depend on the form of PSS. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. The skin involvement is usually general, but in some patients the scalp, face . Specific diseases and conditions that can cause peeling skin include: Infectious diseases Many viral or bacterial infections may cause the skin to peel. Mayo Clinic; 2021. Any part of your body can become dry, but. Make sure yourchild sees his or her healthcare provider for a diagnosis. Although there's no cure for acral peeling skin syndrome, symptoms are usually mild and don't significantly alter your quality of life. Peeling Skin Syndrome (PSS) is a serious skin infection caused by the bacterium Staphylococcus aureus. Skin peeling on fingers is one of many uncomfortable skin symptoms you could experience. Toxic shock syndrome: Toxic shock syndrome is a life-threatening bacterial infection that occurs when specific pathogens get into the body and release toxins. In this section, we are going to explore some of the common causes. AskMayoExpert. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Psoriasis Like eczema,. The main cause of peeling skin syndrome is a defective gene. In addition to the blistered, peeling skin, the person has fever, chills, and weakness. Vitamin deficiency. Reiter's syndrome or reactive arthritis is a disorder that is caused as a result of immune response to bacterial infection. - Dry skin. It commonly causes dry skin, dry eyes, and dry mouth. Mayo Clinic; 2022. - Protect Skin From the Sun. Conditions that may cause skin peeling include: 1 Allergic reactions 2 Infections, including some types of staph and fungal infections 3 Immune system disorders 4 Cancer and cancer treatment 5 Genetic disease, including a rare skin disorder called acral peeling skin syndrome that causes painless peeling of the More . Peeling skin syndrome (PSS) is a rare genetic disorder characterized by continuous peeling of the stratum corneum, which is the outermost layer of the skin. The bacteria release poison (toxins) that cause the skin to blister and peel. Mayo Clinic; 2021. Its more common in the summer and fall. These peeled areas lack a normal barrier function and may become dry and cracked. Muscle wasting and lack of strength in the muscles. Ectasia of the mammary ducts. The disease can be life-threatening and needs treatment. INTRODUCTION. The symptoms of hand-foot syndrome and hand-foot skin reaction can range from mild discomfort to a painful sensation that can prevent you from doing your usual activities. They can include: The symptoms of staphylococcal scalded skin syndrome can be like other health conditions. Because a number of conditions some very severe can cause peeling skin, it's important to get a prompt diagnosis. Another likely risk for peeling lips is a deficiency symptom. AskMayoExpert. These hollow spaces are actually the peeked areas. - Stay Hydrated. What causes skin peeling syndrome? Summary. However, nowadays, any heat-emitting device may cause toasted skin syndrome. Sunburn is a classic example, but other conditions that can cause peeling skin include various forms of dermatitis, eczema, and certain infections. Skin peeling is the hallmark of these conditions. Pemphigus. Atopic dermatitis. When does peeling skin syndrome ( PSS ) occur? The two major forms are acral peeling skin syndrome (APSS; also called localized PSS) and generalized PSS [ 4-7 ]. What Do The Icons On Facebook Messenger Mean? https://www.mayoclinic.org/symptoms/peeling-skin/basics/causes/sym-20050672, Advertising and sponsorship opportunities. Its usually caused by aninfection with a type ofStaphylococcal aureas bacteria. What Does It Mean To Poke Someone In Facebook. Peeling skin syndrome is a group of rare inherited skin disorders characterized by painless, continual, spontaneous skin peeling (exfoliation) due to a separation of the outermost layer of the epidermis (stratum corneum) from the underlying layers. Then, the blisters burst and it leaves a hollow and blank space underneath the skin.

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