what is urea gel used for

Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Urea gradient gel electrophoresis is a simple method for monitoring the denaturant-induced unfolding of proteins. The https:// ensures that you are connecting to the For even more savings, use a GoodRx coupon and pay just a fraction of the retail price. The run duration is dependent on the percentage of used acrylamide, ionic strength of the buffer and gel thickness. Another potential problem that is connected with the sample loading buffer can occur, if the expected product(s) runs at the same level as one of the loading dyes. Birds and saurian reptiles have a different form of nitrogen metabolism that requires less water, and leads to nitrogen excretion in the form of uric acid. Formamide Urea is a Keratolytic emollient that gently dissolves the intercellular matrix, which results in a loosening and shredding of the thick, yellow brittle nail. The cycling of and excretion of urea by the kidneys is a vital part of mammalian metabolism. Is it necessary? The reaction products mostly volatilize into the overhead vapours, and recombine when these condense to form urea again, which contaminates the process condensate. It is best suited for separating single-stranded DNA and small RNA as even minor differences in size can be distinguished. Urate noun. Various commercial urea processes are characterized by the conditions under which urea forms and the way that unconverted reactants are further processed. Our website services, content, and products are for informational purposes only. Bethesda, MD 20894, Web Policies Originally, because it was not economic to recompress the ammonia and carbon dioxide for recycle, the ammonia at least would be used for the manufacture of other products, for example ammonium nitrate or sulfate. Because ammonia is toxic, it is excreted immediately by fish, converted into uric acid by birds, and converted into urea by mammals.[32]. A salt of uric acid; as, sodium urate; ammonium urate. Suitable for general and diabetic foot care. Compare a few possible alternatives below. The first is the complexity of the flow scheme and, consequently, the amount of process equipment needed. Normally urea-gels are used to separate peptide mixtures. Leave the gel into the solution for 5-10 minutes and change the buffer twice. What is urea used for? Molecular Biology, Issue 32, DNA & RNA analysis, denaturing urea polyacrylamide gel electrophoresis, Protocols. In theory, they could operate with no oxygen. A short low percentage acrylamide stacking gel (4%) can have the same band-sharpening effect. In general this method is required to analyze or purify single stranded DNA or RNA fragments, such as synthesized or labeled oligonucleotides or products from enzymatic cleavage reactions. Celleno L. (2018). Once RNA samples have been prepared, denaturing gel electrophoresis is frequently used to visually assess the quality of RNA. Urea preparations are for external use only. Larger gels are used when the expected products/bands are within the range of a few bases, then a longer gel will resolve bands with a difference of a single nucleotide. What is Urea for? Maeno K. (2019). Shake the container well before using the lotion, foam, or suspension formulations. Urea Gel Generic name: Urea Gel [ yoor-EE-a ] Brand name: Uramaxin Drug class: Topical emollients Medically reviewed by Drugs.com. Required equipment: By virtue of its tendency to form porous frameworks, urea has the ability to trap many organic compounds. Ammonia (NH3) first produced by the hydrolysis of urea reacts with nitrogen oxides (NOx) and is converted into nitrogen gas (N2) and water within the catalytic converter. Urea topical may also be used for purposes not listed in this medication guide. (2017). If you notice any redness, irritation, or rash, stop using this medication and contact your provider. Rub in until gel is absorbed. There are many benefits of body scrubs, like softer skin. Fragments between 2 to 500 bases, with length differences as small as a single nucleotide, can be separated using this method1. I have tried as well other options . These products are provided 'AS IS' and 'as available' for use, without warranties of any kind, either express or implied. Those areas tend to be more sensitive and are more likely to get side effects. The gel was1.2%agarose in 1M urea TAE and the . [72] In the evolved procedure, urea was precipitated as urea nitrate by adding strong nitric acid to urine. Urea is commonly used in studies of DNA because it causes uncoiling of DNA molecules. What is urea? The band quality is also dependent on the gel thickness. Heat the solution for 20 seconds in the microwave and mix it gently. Urea is the least concerning reactor in instant ice packs, but it can cause nausea, vomiting, dizziness, drowsiness, and confusion if enough is swallowed. Ships from Fulshear, TX. This was accomplished by depressurizing the reaction solution in stages (first to 18 25 bar and then to 2 5 bar) and passing it at each stage through a steam-heated carbamate decomposer, then recombining the resultant carbon dioxide and ammonia in a falling-film carbamate condenser and pumping the carbamate solution into the previous stage. Urea is used in skin preparation to soften keratin, treating psoriasis, eczema, and corns and calluses . For an English translation of the relevant passage, see: Peter Shaw. TEMED Similar bacteria species to H. pylori can be identified by the same test in animals such as apes, dogs, and cats (including big cats). Urea 42% Nail Gel is a Keratolytic emollient that was developed to treat thick, dystrophic fungal (Onychomycosis) nails. UseUrea Nail Gel (Topical)exactly as directed on the label, or as prescribed by your doctor. Theyre fast, easy-to-use and free! dogs) have a much more concentrated urine and it contains a higher urea amount than normal human urine; this can prove dangerous as a source of liquids for consumption in a life-threatening situation (such as in a desert). Urea can also help exfoliate dead skin buildup and may help target fungal infections. The water-retaining property of the stratum corneum largely comes from a group of substances known as natural moistening factors (NMFs). These tubes are fabricated by ATI Wah Chang (USA) using its Omegabond technique.[58]. . The liver forms it by combining two ammonia molecules (NH3) with a carbon dioxide (CO2) molecule in the urea cycle. Urea noun. National Library of Medicine Urea is then dissolved into the blood (in the reference range of 2.5 to 6.7mmol/L) and further transported and excreted by the kidney as a component of urine. By action of the urea transporter 2, some of this reabsorbed urea eventually flows back into the thin descending limb of the tubule,[34] through the collecting ducts, and into the excreted urine. 20th Arab Fertilizer International Annual Technical Conference, Tunisia. Weve got answers. Examples include carbamide peroxide, allantoin, and hydantoin. No one has proposed a radical alternative to the approach. -timjim-. Isocyanic acid HNCO and ammonia NH3 results from the thermal decomposition of ammonium cyanate [NH4]+[OCN], which is in chemical equilibrium with urea: This reaction is at its worst when the urea solution is heated at low pressure, which happens when the solution is concentrated for prilling or granulation (see below). Find out some side effects of it and guaifenesin, its main ingredient. Fill up the volume with deionized, distilled water. It is fortunate that the urea conversion reaction is slow. Urea Gel It is widely used by podiatrist to treat patients with thick, mycotic nails. Synthetic urea is also commonly added to baked goods and wines to help with fermentation. Denaturing urea polyacrylamide gel electrophoresis (Urea-PAGE) is useful to analyze or separate single-stranded DNA or RNA fragments as well as radionucleotide- or fluorescent-labeled samples. Later process schemes made recycling unused ammonia and carbon dioxide practical. In particular, its commonly used to treat conditions of the feet like: Urea creams and lotions have been used as a successful treatment for: Urea creams and ointments appear on the World Health Organizations list of essential medications for a basic healthcare system. Dismount the gel from the casting chamber and assembly it to the gel apparatus according to manufactures instructions. The denaturing gel is a time-intensive procedure requiring . Observe the migration of the marker dyes until the dye front reached the lower end of the gel. Urea topical is for use only on the skin. pyrrolidone carboxylic acid Urea is used in a variety of skin care products to target general skin dryness or medical conditions associated with dry or itchy skin. Few side effects if used for short periods of time, Available in different topical forms (e.g., cream, foam, gel, lotion). Ethanol, Table 1: Reagents and solutions needed for various acrylamide concentrations and volumes for resolving single stranded oligonucleotides. Warnings Effectively removes thick and hard skin due to repeated friction or pressure. Topical urea in skincare: A review. It's available over-the-counter in different formulations. Use your medicine exactly as directed on the label, or as prescribed by your doctor. Besides its role as carrier of waste nitrogen, urea also plays a role in the countercurrent exchange system of the nephrons, that allows for reabsorption of water and critical ions from the excreted urine. ", "Optical parametric oscillator using urea crystal", International Chemical Safety Cards: UREA, "Evaluation of flow injection analysis for determination of urea in sheep's and cow's milk", "A microscale method for colorimetric determination of urea in soil extracts", page 198: Process CXVIII: The native salt of urine, "Why Pee is Cool entry #5 "How Pee Unites You With Rocks", "Ueber knstliche Bildung des Harnstoffs", "Inorganic Chemicals: Ammonium Carbamate", "Use of DP28W Reduces Passivation Air in Urea Plants", "Rotoform Urea Particles The Sustainable Premium Product", "Observations sur l'urine humaine, & sur celle de vache & de cheval, compares ensemble", "Extrait dun premier mmoire des cit. Creighton in 1979. 40% urea effectively debrides the diseased nail while leaving healthy nail intact and unaffected. Urea is available as a generic medication and may be significantly cheaper compared to the brand version. The information contained in the Truven Health Micromedex products as delivered by GoodRx is intended as an educational aid only. [60] But at the end of the 1970s three companies began to develop fluidized-bed granulation. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Ammonium carbamate solutions are notoriously corrosive to metallic construction materials, even more resistant forms of stainless steel especially in the hottest parts of the plant such as the stripper. Apply generously to the nail and allow the medicine to dry. Urea can cause algal blooms to produce toxins, and its presence in the runoff from fertilized land may play a role in the increase of toxic blooms. [6] Dissolved in water, it is neither acidic nor alkaline. At strengths above 10 percent, according to the same 2018 review, urea creams and lotions have a keratolytic action, meaning they help exfoliate dry and flaking skin. Use the missed dose as soon as you remember. It is not known whether urea topical passes into breast milk or if it could harm a nursing baby. Abstract. Urea topical may also be used for purposes not listed in this medication guide. Lotions and creams often contain urea to help moisturize dry or flaking skin or to act as a chemical exfoliator. When your body breaks down protein, it naturally makes urea, which can be detected in the urine. The Rejuvenating Post-Summer Skin Care You Need, 14 Best Pillowcases for Hair and Skin in 2022, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI. The migration of the sample is dependent on the chosen acrylamide concentration. Urea is usually applied to the affected area(s) 2 times a day. 8600 Rockville Pike Keep the medicine container tightly closed when not in use. Gel dryer or scanner, Reagents and Solutions: Although it is necessary to compress gaseous carbon dioxide to this pressure, the ammonia is available from the ammonia plant in liquid form, which can be pumped into the system much more economically. Loading buffer has to be applied to empty pockets to maintain equal conditions during the run. A 2019 review of studies found that urea enhanced the function of oral and topical antifungal treatments for onychomycosis, which is a fungal infection of the toenail. Glycerol and urea can be used to increase skin permeability in reduced hydration conditions. People use urea cream for many skin conditions, such as eczema, psoriasis, and athlete's foot. Careers, Assemble the gel according to manufacturers description and fix the gel in the gel-casting chamber. Stop using urea topical and call your doctor at once if you have: This is not a complete list of side effects and others may occur. The most common impurity of synthetic urea is biuret, which impairs plant growth. In 1828 Friedrich Whler discovered that urea can be produced from inorganic starting materials, which was an important conceptual milestone in chemistry. Even if the medication is working, you may experience some unwanted side effects. Urea topical is also used to soften damaged fingernails or toenails so they can be removed without surgery. In situations such as muscle wasting, 1mmol of excessive urea in the urine (as measured by urine volume in litres multiplied by urea concentration in mmol/L) roughly corresponds to a muscle loss of 0.67gram. government site. 'The deposition of urate crystals in the joints leads to gout.'; Urea noun. Urea Nail Gel may also be used for purposes not listed in this medication guide. Skip the missed dose if it is almost time for your next scheduled dose. Silk and satin pillowcases are considered the best for preserving good hair and skin. DESCRIPTION: UREA Nail Gel 45% is a keratolytic emollient, which is a gentle, yet potent, tissue softener for nails and/or skin. However, a doctor can best advise you whether a urea cream is suitable for your child. It may also be used to help remove dead tissue in some . Each gram of UREA Nail Gel 45% contains 45% Urea, camphor, edetate disodium, eucalyptus oil, hydroxyethyl cellulose, menthol, propylene glycol and purified water. "[69][70] Berzelius made further improvements to its purification[71] and finally William Prout, in 1817, succeeded in obtaining and determining the chemical composition of the pure substance. The information within all other sections is proprietary to Everyday Health. 0.5 x TBE solution Moisturisers for the treatment of foot xerosis: A systematic review. Tadpoles excrete ammonia, but shift to urea production during metamorphosis. You can learn more about how we ensure our content is accurate and current by reading our. Urea 42% Nail Gel is indicated for use as a topical treatment for debridement of Mycotic Nails. Unlike greasy creams, it's a light clear gel that's easily absorbed and penetrates quickly into . Do not use this medicine on open wounds, burns, or areas of swollen skin. Ammonia is smaller, more volatile and more mobile than urea. Non-symmetric ureas can be accessed by the reaction of primary or secondary amines with an isocyanate. There are many brands and forms of urea topical available and not all brands are listed on this leaflet. If youre sensitive to a different ingredient, urea may make your reaction worse. Avoid putting urea on or near your eyes, lips, and genitals (groin area) unless your provider tells you to do so. This mechanism is important to prevent the loss of water, maintain blood pressure, and maintain a suitable concentration of sodium ions in the blood plasma. Repaired skin is the secret to youthful skin. The gel is ready for further processing using a vacuum gel dryer or direct scanning of the gel. Sun exposure can take its toll. The advantage of prills is that, in general, they can be produced more cheaply than granules and that the technique was firmly established in industrial practice long before a satisfactory urea granulation process was commercialized. The site is secure. Among these NMFs are: Urea is used in a variety of skin care products to target general skin dryness or medical conditions associated with dry or itchy skin. Find everything you need to know about Kerasal (Salicylic Acid And Urea Topical), including what it is used for, warnings, reviews, side effects, and interactions. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. .mw-parser-output .ib-chembox{border-collapse:collapse;text-align:left}.mw-parser-output .ib-chembox td,.mw-parser-output .ib-chembox th{border:1px solid #a2a9b1;width:40%}.mw-parser-output .ib-chembox td+td{width:60%}. A water-soluble organic compound, CO (NH 2) 2, formed by the metabolism of proteins and excreted in the urine. Despite a theoretical basis for the use of urea for the treatment of onychomycosis, the evidence-base for this treatment has not been . Use a mild soap or cleanser to wash the skin or nail area to be treated. ideally between 1-5 l. Urea is a humectant. Remove the gel from the chamber and loosen the clamps. Use ultrapure urea and mix with the desired amount of acrylamide. Instead of feeding carbon dioxide gas directly to the reactor with the ammonia, as in the total recycle process, the stripping process first routes the carbon dioxide through a stripper (a carbamate decomposer that operates under full system pressure and is configured to provide maximum gas-liquid contact). 1200ml 1000ml 650 ml 600 ml 500 ml 300 ml. School of Biological Sciences, Nanyang Technological University, Singapore - NTU, Singapore-MIT Alliance for Reserach and Technology (SMART). Do not puncture or burn an empty foam canister. The treated nail should be easily removed after several days. Urea is one treatment option, which is thought to improve the efficacy of topical and oral antifungal agents. In this cycle, amino groups donated by ammonia and L-aspartate are converted to urea, while L-ornithine, citrulline, L-argininosuccinate, and L-arginine act as intermediates. A 2013 study suggested that urea may help some medications penetrate through your skin. This property can be exploited to increase the solubility of some proteins. [36], Urea is readily quantified by a number of different methods, such as the diacetyl monoxime colorimetric method, and the Berthelot reaction (after initial conversion of urea to ammonia via urease). Properties. UREA (yoo REE uh) is used to soften thick, rough, or dry skin caused by certain skin conditions. Some forms of urea are safe to use on the face, especially if they are milder. It serves as the source of nitrogen for the biosynthesis of protein with the mediation of bacteria and other microorganisms. Urea Nail Gel (for the skin) is used to soften rough or dry skin caused by skin conditions such as eczema, psoriasis, keratosis, and others. Urea topical (for the skin) is used to soften rough or dry skin caused by skin conditions such as eczema, psoriasis, keratosis, and others. This amide has two amino groups (NH2) joined by a carbonyl functional group (C(=O)). Urea's high aqueous solubility reflects its ability to engage in extensive hydrogen bonding with water. Choose the percentage of polyacrylamide that suits your separation requirements, a higher polyacrylamide concentrations will resolve lower molecular weight fragments. Because the carbon dioxide feed is recovered from ammonia synthesis gas, it contains traces of hydrogen that can mingle with passivation air to form an explosive mixture if allowed to accumulate. Urea 42% Nail Gel penetrates the nail to soften and thin the nail allowing for enhanced absorption of an antifungal solution. Urea is widely used in fertilizers as a source of nitrogen (N) and is an important raw material for the chemical industry. Urea is only for external use on the skin and nails. your skin naturally produces urea; it regulates your skin's moisture content and is an essential component of your NMF. When using. Denaturing urea polyacrylamide gel electrophoresis (Urea-PAGE) is useful to analyze or separate single-stranded DNA or RNA fragments as well as radionucleotide- or fluorescent-labeled samples. WO 95/00674 (1995). Urea 42% Nail Gel is a Keratolytic emollient that was developed to treat thick, dystrophic fungal (Onychomycosis) nails. Contact your doctor immediately if you experience any of the following: The following side effects may get better over time as your body gets used to the medication. It is used as a marker of renal function, though it is inferior to other markers such as creatinine because blood urea levels are influenced by other factors such as diet, dehydration,[18] and liver function. Precast TBE Urea gels are polymerized polyacrylamide gel slabs containing tris base, boric acid, EDTA, and urea. Follow all directions on th medicine label. Avoid introducing air bubbles. Urea foam canisters can contain a lot of pressure. Nakamura, S. (2007) "The Toyo Urea Granulation Technology". Kazachenko, Aleksandr S.; Issaoui, Noureddine; Medimagh, Mouna; Yu. Urea in concentrations up to 10 M is a powerful protein denaturant as it disrupts the noncovalent bonds in the proteins. Unless there is a specific reason you need the brand, the generic medication will be a better value. However, up to 15 l can be loaded which still ensures acceptable resolution. If this medication gets in your eyes, nose, mouth, rectum, or vagina, rinse with water. When applying urea topical to the nails, avoid getting any medicine on the cuticles or surrounding skin. Urea may also increase the absorption of some of the other ingredients in the product youre using. Urea is synthesized in the body of many organisms as part of the urea cycle, either from the oxidation of amino acids or from ammonia. DOI: 10.1016/j.molliq.2022.119859, cycling of and excretion of urea by the kidneys, thin descending limb of the loop of Henle, "Solubility of Various Compounds in Glycerine", Ullmann's Encyclopedia of Industrial Chemistry, "Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain", "Carbamide Peroxide Drops GENERIC NAME(S): CARBAMIDE PEROXIDE", "Treatment of euvolemic hyponatremia in the intensive care unit by urea", "Induction of therapeutic abortion by intra-amniotic injection of urea", "How to measure renal function in clinical practice", "Paclitaxel-Coated Balloons Reduce Restenosis After Femoro-Popliteal Angioplasty", "Drug-Coated Balloons for Coronary and Peripheral Interventional Procedures", "Intrinsic coating morphology modulates acute drug transfer in drug-coated balloon therapy", "Lacura Multi Intensive Serum Review Excellent value for money Lacura Multi Intensive Serum "Aqua complete", "Urea as an Ice Nucleant for Supercooled Clouds", 10.1175/1520-0469(1966)023<0197:UAAINF>2.0.CO;2, "Dyeing FAQ: What is urea for, in dyeing? [73] This behaviour can be used to separate mixtures, e.g., in the production of aviation fuel and lubricating oils, and in the separation of hydrocarbons. Pricing based on most commonly-filled versions: 1 bottles (28.35g) 40% of urea cream. sharing sensitive information, make sure youre on a federal Here are some: 1. It was first used by Dr. W. Friedrich in 1892. Urea topical (for the skin) is used to soften rough or dry skin caused by skin conditions such as eczema, psoriasis, keratosis, and others. For this reason, old, stale urine has a stronger odor than fresh urine. The E-Gel EX gels have a sensitivity that is 5X greater than that using ethidium bromide. Trucks and cars using these catalytic converters need to carry a supply of diesel exhaust fluid, also sold as AdBlue, a solution of urea in water. How does urea affect Tm of DNA? Urea 40% "dissolves the intercellular matrix"[12][13] of the nail plate. For a denaturing acrylamide gel of 20 cm x 22 cm x 1.5 mm, 60 ml of gel solution and for a 10.1 x 8.2 cm x 1 mm gel 5 ml gel solution is sufficient. (1943) "Boerhaave's Ontdekking van het Ureum" (Boerhaave's discovery of urea), This page was last edited on 13 October 2022, at 05:57. Pour the gel immediately using a serological pipette and an automatic pipette aid between the two glass plates. Apply a thin layer of this medicine to the affected skin and rub it in as completely as possible. Do Not Make Your Feet Wait Any Longer, Buy Today! If you are using this medication on thickened nails, which are often due to fungal infection, you may want to ask your provider for antifungal recommendations to get the best effect. Urea topical is also used to soften damaged. Get it as soon as Mon, Oct 17. For example, RNase A remains active in conditions such as pH ranges between 2 and 10 [9,10], solutions of up to 8 M urea , extreme temperatures (15-80C) . Before applying urea, make sure the affected area(s) of skin are clean and dry. The BlueTec system, for example, injects a water-based urea solution into the exhaust system. Do not use this medicine without a doctor's advice if you are pregnant. In 1828, the German chemist Friedrich Whler 1, then at the Polytechnic School (now Technical University) of Berlin, published a seminal . And stacking gel is definitely important to make sure the proteins arrange themselves in such a way that during separation, it can resolve nicely in the resolving gel. ; Urea preparations may be used in children from 1 year and upwards if there is a diagnosed dry skin condition and it has been recommended by the . Hyperkeratosis (abnormally thick or tough skin or nails) Urea dosage forms bottle of cream 227g of 39% 28.35g of 40% 85g of 40% 198.4g of 40% 227g of 41% 142g of 47% bottle of gel (2022) Journal of Molecular Liquids, 363, art. The resulting dense and energetically favourable hydrogen-bond network is probably established at the cost of efficient molecular packing: The structure is quite open, the ribbons forming tunnels with square cross-section. Urea 40% is indicated for psoriasis, xerosis, onychomycosis, ichthyosis, eczema, keratosis, keratoderma, corns, and calluses. It is also used to soften and remove damaged or diseased nails without surgery. Do not take by mouth. Urea and Foot Care Now, youll enjoy a streamlined experience created specifically for healthcare providers. Avoid contact with eyes. Recommended by experts and vetted by us, we narrowed it down to 10 skin care gifts worth picking in 2022. Urea topical may work best if the skin or nail to be treated is left slightly damp before the medicine is applied. Pull away the spacers and carefully dissemble the glass plates. With any medication, there are risks and benefits. Doesn't usually treat the cause of the abnormal skin (e.g., eczema, psoriasis) or nail (e.g., fungal infection), Usually takes several weeks to fully work. High concentrations in the blood can be damaging. For 100-700 bp I would run a 2.5% agarose gel, and . Product and Attributes: Softens hyperkeratotic nail units Penetrates intercellular matrix Facilitates nail debridement Masks odor caused by fungal and bacterial infections The method was first introduced for this purpose by T.E. In commercial cosmetics, urea is made synthetically in a lab. If the expected bands differ in more than 10 nucleotides, smaller gels will be suitable to resolve the fragments. Pipette and Pipette tips KERA Nail Gel Kera Nail Gel 47% Urea Gel is a high-potency nail treatment in a vehicle containing, Tea Tree Oil, Menthol, Camphor and Eucalyptus Oil. Only diseased or dystrophic nails are removed, as there is no effect on healthy portions of the nail. Prices for urea start at just $12.53 with a GoodRx coupon. This Moisturizers item is sold by BayHarborBeauty. will also be available for a limited time. To purify the resulting crystals, they were dissolved in boiling water with charcoal and filtered. Urea can be produced as prills, granules, pellets, crystals, and solutions. [19][20] Urea, when used as an excipient in small doses (~3g/mm2) to coat DCB surface was found to form crystals that increase drug transfer without adverse toxic effects on vascular endothelial cells.[21]. Allegheny Technologies, Inc. (2012) "Increasing Urea Plant Capacity and Preventing Corrosion Related Downtime". The stripping concept, developed in the early 1960s by Stamicarbon in The Netherlands, addressed both problems. Check with your pharmacist if urea cream is the right option for you.

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