nplate side effects rash

pain or tenderness around the eyes and cheekbones, Burning pain, warmth, swelling, or redness of the hands and feet, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals. Common side effects of Nplate include: abdominal pain, dizziness, insomnia, limb pain, and myalgia. Other side effects include: dyspepsia, paresthesia, and shoulder pain. * Approximation only. Mild side effects of Nplate that have been reported include: dizziness* pain in your joints and muscles* trouble sleeping belly pain upset stomach tingling, burning, or numbness of your skin. This survey is being conducted by the WebMD marketing sciences department. What should be considered before receiving Nplate? Adverse drug reactions in adults with a 5% higher patient incidence in Nplate versus placebo were Arthralgia (26%, 20%), Dizziness (17%, 0%), Insomnia (16%, 7%), Myalgia (14%, 2%), Pain in Extremity (13%, 5%), Abdominal Pain (11%, 0%), Shoulder Pain (8%, 0%), Dyspepsia (7%, 0%), and Paresthesia (6%, 0%). Here are a few tips that might help guide your discussion: Remember, your doctor and other healthcare professionals are available to help you. Different individuals may respond to medication in different ways. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. To monitor your response to Nplate, your doctor will order blood tests to check your platelet level. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The following adverse reactions (at least 5% incidence and at least 5% more frequent with Nplate compared with placebo or standard of care) occurred in Nplate patients with ITP duration up to 12 months: bronchitis, sinusitis, vomiting, arthralgia, myalgia, headache, dizziness, diarrhea, upper respiratory tract infection, cough, nausea and oropharyngeal pain. Available for Android and iOS devices. [Ref], Very common (10% or more): Grade 2 or higher bleeding event (15%), Common (1% to 10%): Bone marrow reticulin formation increased 2 grades or more, bone marrow collagen fibrosis increased to grade 4, grade 4 bone marrow collagen fibrosis, bone marrow disorder, thrombocytopenia, anemia, thrombocytosis, bone marrow reticulin deposition, anemia, reticulin increased, serious bleeding event, Uncommon (0.1% to 1%): Aplastic anemia, bone marrow failure, leukocytosis, splenomegaly, thrombocythemia, platelet count increased, platelet count abnormal, blood lactate dehydrogenase increased, Frequency not reported: Marrow fibrosis with collagen[Ref], Common (1% to 10%): Palpitations, flushing, hematoma, hypertension, peripheral ischemia, peripheral embolism, Uncommon (0.1% to 1%): Myocardial infarction, heart rate increased, deep vein thrombosis, hypotension, phlebitis, thrombophlebitis superficial, thrombosis, erythromelalgia, blood pressure increased, Frequency not reported: Congestive heart failure[Ref], Uncommon (0.1% to 1%): Multiple myeloma, myelofibrosis, Frequency not reported: Progression of myelodysplastic syndromes (MDS) to acute myelogenous leukemia (AML), blast cell counts transiently increased[Ref], Very common (10% or more): Headache (up to 36.2%), dizziness (up to 17%), Common (1% to 10%): Paresthesia, migraine, Uncommon (0.1% to 1%): Clonus, dysgeusia, hypoesthesia, hypogeusia, neuropathy peripheral, transverse sinus thrombosis, vertigo[Ref], Very common (10% or more): Upper respiratory tract infection (up to 31%), nasopharyngitis (up to 26.2%), oropharyngeal pain (up to 25%), epistaxis (22.6%), cough (up to 17.3%), Common (1% to 10%): Pulmonary embolism, sinusitis, bronchitis, dyspnea, nasal congestion, rhinorrhea, Uncommon (0.1% to 1%): Dry throat, painful respiration, Frequency not reported: Upper respiratory tract infection, pneumonia[Ref], Very common (10% or more): Arthralgia (up to 26%), back pain (up to 15.8%), pain in extremity (up to 15.6%), myalgia (up to 14%), Common (1% to 10%): Shoulder pain, muscle spasms, bone pain, musculoskeletal pain, Uncommon (0.1% to 1%): Muscle tightness, muscle weakness, muscle twitching[Ref], Very common (10% or more): Contusion (up to 41%), pyrexia (up to 24%), fatigue (up to 23.3%), Common (1% to 10%): Influenza-like illness, pain, asthenia, chills, injection site reaction, chest pain, peripheral swelling, Uncommon (0.1% to 1%): Injection site hemorrhage, malaise, feeling hot, feeling jittery, body temperature increased[Ref], Very common (10% or more): Diarrhea (up to 20%), nausea (up to 19.4%), upper abdominal pain (14%), abdominal pain (up to 11%), vomiting (up to 10.5%), Common (1% to 10%): Dyspepsia, gastroenteritis, constipation, gingival bleeding, mouth hemorrhage, upper abdominal pain, toothache, Uncommon (0.1% to 1%): Rectal hemorrhage, breath odor, dysphagia, gastroesophageal reflux disease, hematochezia, stomach discomfort, stomatitis, tooth discoloration[Ref], Very common (10% or more): Petechiae (18.6%), rash (up to 15%), Common (1% to 10%): Angioedema, pruritus, ecchymosis, purpura, urticaria, Uncommon (0.1% to 1%): Alopecia, photosensitivity reaction, acne, dermatitis contact, dry skin, eczema, erythema, exfoliative rash, hair growth abnormal, prurigo, rash papular, rash pruritic, skin nodule, skin odor abnormal, face edema[Ref], Very common (10% or more): Insomnia (up to 16%), Uncommon (0.1% to 1%): Depression, abnormal dreams, irritability[Ref], Very common (10% or more): Peripheral edema (up to 12.5%), Uncommon (0.1% to 1%): Alcohol intolerance, anorexia, appetite decreased, dehydration, gout, weight decreased, weight increased[Ref], Very common (10% or more): Antibodies to this drug (up to 16%), Common (1% to 10%): Preexisting antibodies to this drug, influenza, ear infection, Uncommon (0.1% to 1%): Localized infection, neutralizing antibodies, Frequency not reported: Hypersensitivity reactions including angioedema and anaphylaxis (postmarketing reports)[Ref], Common (1% to 10%): Urinary tract infection, Uncommon (0.1% to 1%): Protein urine present, vaginal hemorrhage[Ref], Uncommon (0.1% to 1%): Conjunctival hemorrhage, accommodation disorder, blindness, eye disorder, eye pruritus, lacrimation increased, papilledema, visual disturbances[Ref], Uncommon (0.1% to 1%): Portal vein thrombosis, transaminase increased[Ref], 1. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Less common but important side effects can include: Dizziness, indigestion, insomnia, and tingling in the hands and feet. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. If you need to take Nplate over a long period of time and youre concerned about long-term side effects, talk with your doctor or pharmacist. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. The lists below describe some of the more common side effects that Nplate may cause. a feeling of general discomfort called malaise. KANJINTI is indicated for adjuvant treatment of HER2 overexpressing node positive or node negative (ER/PR negative or with one high risk feature [see Clinical Studies (14.1)]) breast cancer as part of a treatment regimen consisting of doxorubicin, cyclophosphamide, and either paclitaxel or. The safety profile of Nplate was similar across patients, regardless of ITP duration. The most common side effects of Doptelet are: Headache Tiredness Bruising Nosebleed Upper respiratory tract infection Joint pain Gum bleeding Purple or red spots on your skin Runny nose Serious side effects Doptelet is a TPO-RA and TPO-RAs have been associated with blood clots. Platelets help your blood to form clots. All rights reserved. The users guide to prescription drugs and supplements: Finding the right medication is important Let RateADrug help. All patients were negative for neutralizing activity to TPO. This medicine is used to treat low platelets caused by chronic idiopathic thrombocytopenic purpura ( ITP) or a bone marrow syndrome caused by radiation sickness. The samples from patients that tested positive for binding antibodies were further evaluated for neutralizing capacity using a cell-based bioassay. In the placebo-controlled studies, headache was the most commonly reported adverse drug reaction, occurring in 35% of patients receiving Nplate and 32% of patients receiving placebo. Immunogenicity assay results are highly dependent on the sensitivity and specificity of the assay used in detection and may be influenced by several factors, including sample handling, concomitant medications, and underlying disease. romiplostim side effectsmatlab linear regression example November 7, 2022 . Adverse Reactions Identified in Two Placebo-Controlled Studies. On the 18th and 19th my whole upper lymph system hurt more severely, burning pain in my spine and sternum. If I reach a certain platelet level, can I stop receiving Nplate injections. But you must receive this dose immediately after being exposed to the radiation. Learn about eight types of ITP treatment, how each one works, potential side effects, and. Nplate Side Effects Headache, joint/muscle pain, dizziness, heartburn, abdominal pain, tingling/numbness in hands/feet, and trouble sleeping may occur. They can talk with you about the risks and benefits of Nplate treatment. We comply with the HONcode standard for trustworthy health information. A bleeding time test helps your doctor determine how quickly your blood clots to stop bleeding. This medicine is used to treat low platelets caused by chronic idiopathic thrombocytopenic purpura (ITP) or a bone marrow syndrome caused by radiation sickness. Nonimmunogenic second-generation thrombopoietic growth factors (romiplostim [Nplate]; eltrombopag [Promacta]) are used for the treatment of . Notify your provider of any of these side effects. Any vaccine can cause side effects. However, if you think youre having a medical emergency, you should call 911 or your local emergency number. Now the old Niu blood pressure meds and beer is back, but diet to lower cholesterol and blood pressure Niu Wazi has not types of medicines for high blood pressure come back. Cerner Multum, Inc. "UK Summary of Product Characteristics." The incidence of new binding antibody development was 3.8% (7/184) to romiplostim and 2.2% (4/184) were positive for binding, non-neutralizing antibodies to TPO; two patients were positive for binding antibodies to both romiplostim and TPO. The following side effects are common (occurring in greater than 30%) for patients taking Nplate: Headache fatigue Coughing up blood These side effects are less common side effects (occurring in about 10-29%) of patients receiving Nplate: Joint pain (arthralgia) Dizziness Insomnia Muscle pain (myalgia) Pain in extremity Abdominal pain Nausea severe low platelet count in unresponsive chronic ITP, bone marrow failure from acute radiation toxicity, increased reticulin bone marrow deposition, inflammation of the tissue lining the sinuses, fluid retention in the legs, feet, arms or hands, obstruction of a blood vessel by a blood clot, a significant type of allergic reaction called anaphylaxis, a type of allergic reaction called angioedema, a condition affecting the body causing pain, redness, and swelling called erythromelalgia, blockage or narrowing of the portal vein by a blood clot. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Other drugs that have the same active ingredients (e.g. Here are some of the severe and potentially long-term side effects to be aware of when considering or taking propranolol: Hallucinations Cold hands or feet Muscle weakness Muscle cramps Shortness of breath Memory loss Fluid retention Blood sugar changes Insomnia and nightmares Allergic reaction Vomiting Shakiness Weight gain Skin rash Common Nplate side effects: Abdominal pain (203 reports) Acute kidney failure (158 reports) Acute myeloid leukaemia (210 reports) Agranulocytosis (188 reports) Anaemia (331 reports) Appetite - decreased (111 reports) Atrial fibrillation/flutter (117 reports) And they want you to get the best care possible. When receiving Nplate, notice when your dizziness occurs and how long it lasts. If you have hair loss after starting Nplate, talk with your doctor. You may have questions about Nplate and your treatment plan. Promacta, prednisone, dexamethasone, triamcinolone, Decadron. Swelling of the glands in the cheeks or neck or temporary pain and . Nplate has active ingredients of romiplostim. The most common side effects of Nplate in adults include: headache joint pain dizziness trouble sleeping muscle tenderness or weakness pain in arms and legs stomach (abdomen) pain shoulder pain indigestion tingling or numbness in hands and feet bronchitis inflammation of the sinuses (sinusitis) vomiting diarrhea upper respiratory tract infection Nplates mechanism of action mimics how your bodys natural thrombopoietin works. Table 3. This outcome was referred to as treatment-free remission. For these people, their Nplate dosage was decreased over time, based on their platelet level, until they no longer needed to take Nplate. Shoulder pain. Examples of possible ITP treatments include: Below are answers to some common questions about taking Nplate. This bleeding condition is caused by a lack of platelets in the blood. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. "Product Information. Find out about the most common complications of ITP, and when you should contact a doctor. Below are commonly used dosages, but always take the dosage your doctor prescribes. This is not a complete list of side effects and others may occur. Of these 9 patients, 2 patients had pre-existing binding non-neutralizing antibodies to TPO. Without enough platelets, you may bleed inside your body or have trouble stopping a bleed from within. To learn about other mild side effects, talk with your doctor or pharmacist, or read Nplates medication guide. If you have an allergic reaction to Nplate, tell your doctor right away. If you have ITP, you may have bruises or tiny red or purple dots on your skin. Among 291 adult patients with ITP who received Nplate in the single-arm extension study, the incidence rates of the adverse reactions occurred in a pattern similar to those reported in the placebo-controlled clinical studies. . Talk with your doctor about your health history before you take Nplate. What Are Side Effects of Nplate? Healthline Media does not provide medical advice, diagnosis, or treatment. Seborrheic eczema is a type of eczema that most often affects . 12 Medicines That Could Help. Nplate was studied in two randomized, placebo-controlled, double-blind studies that were identical in design, with the exception that Study 1 evaluated nonsplenectomized patients with ITP and Study 2 evaluated splenectomized patients with ITP. Of the patients with positive binding antibodies that developed to romiplostim or to TPO, four patients had neutralizing activity to romiplostim and none had neutralizing activity to TPO. This lower platelet count increases the risk of bleeding, so precautions should be taken, and any bruising or bleeding should be reported to your healthcare provider.

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