type 2 diabetes stem cell clinical trials 2022

Efficacy of autologous bone marrow-derived mesenchymal stem cell and mononuclear cell transplantation in type 2 diabetes mellitus: a randomized, placebo-controlled comparative study. The dosage of hypoglycemic agents was reduced in all patients, of whom 6 (50%) had a decrement of more than 50% and 1 (6.25%) discontinued the hypoglycemic agents. If you take pioglitazone (Actos) or a combination drug with pioglitazone in it (Actoplus Met, Duetact), call your . Sun Y., Shi H., Yin S., et al. Lancet (1990) 336(8726):1323. Mitochondrial transfer from mesenchymal stem cells to macrophages restricts inflammation and alleviates kidney injury in diabetic nephropathy mice via PGC-1. Extracellular vesicles from human urinederived stem cells merged in Author contributions: Zhang F designed the report; Lian XF, Lu DH, Liu HL, Liu YL, Yang Y, Lin Y, Zeng QX, Huang ZJ, Xie F, Huang CH, Wu HM, Long AM, and Deng LP collected the patients clinical data; Lian XF and Han XQ analyzed the data and wrote the paper. official website and that any information you provide is encrypted BMC Mol Cell Biol. Dordrecht: Springer Netherlands; (1996). about navigating our updated article layout. Combinatorial human progenitor cell transplantation optimizes islet regeneration through secretion of paracrine factors. Cai J, Wu Z, Xu X, Liao L, Chen J, Huang L, Wu W, Luo F, Wu C, Pugliese A, Pileggi A, Ricordi C, Tan J. Umbilical Cord Mesenchymal Stromal Cell With Autologous Bone Marrow Cell Transplantation in Established Type 1 Diabetes: A Pilot Randomized Controlled Open-Label Clinical Study to Assess Safety and Impact on Insulin Secretion. A Peripheral T Cell Lymphoma Clinical Trials Recruiting. Galleu et al. Potential mechanisms include protection of endogenous islets and restoration of, MeSH To explore the therapeutic effectiveness and mechanism of hUC-MSC infusion, we conducted the present study to evaluate the effectiveness and safety of hUC-MSC infusion in treating T2DM. Firstly, transient transfection is extremely unstable, thus resulting in short-lasting therapeutic effects. Besides, the therapeutic mechanisms of MSCs to combat T2DM have not been thoroughly understood. Cerf ME. The authors acknowledge the financial support from all of the funders. The study by Sood et al. Non-Hodgkins lymphoma is a type of cancer that arises in the lymphatic system, which is responsible for fighting disease and toxins in the body. Planat-Benard V., Varin A., Casteilla L. MSCs and inflammatory cells crosstalk in regenerative medicine: concerted actions for optimized resolution driven by energy metabolism. Likewise, the abnormal changes in peripheral or tissue-resident immune cells and their regulatory function always accompany the development of diabetes, indicating that immune cells such as T lymphocytes (T cells), macrophages, and natural killer cells (NK cells) are considered to participate in the progression of T2DM concomitantly [21]. Webber B. R., Osborn M. J., McElroy A. N., et al. MSCs also facilitate the inhibition of MG53, which is an E3 ligase that promotes the ubiquitinoylation of IRS-1 in skeletal muscles. This site needs JavaScript to work properly. Therefore, the ability to determine the dose, in vivo distribution, and extended viability of MSCs in patients is crucial in developing MSC-based therapies and elucidating the in vivo therapeutic mechanism of administered MSCs for T2DM treatment [81]. Neither the cause of T1D nor the means to prevent it are currently known. The results of our study suggest that hUC-MSC treatment can improve glycemia, restore islet cell function, and safely reduce the dosage of hypoglycemic agents required by the patient. FOIA [PMC free article] [Google Scholar . GLP-1RAs have shown a broad range of therapeutic effects in various diseases aside from their antidiabetic effects. ICYMI: The Juvenile Diabetes Cure Alliance review of active #T1D clinical trials revealed only 2% are aimed at delivering practical cures, treatments which will substantially reduce or eliminate . Human umbilical cord mesenchymal stem cells therapy for insulin resistance: a novel strategy in clinical implication. Before In addition, the therapeutic effects of MSCs can be enhanced when combined with biological materials, such as collagen and hydrogels. Leibacher J., Dauber K., Ehser S., et al. This is the first clinical trial of hUC-MSC infusion for T2DM treatment approved by the China Medical Biotech Association. Besides, BM-MSCs are able to alleviate endoplasmic reticulum stress- (ERS-) induced apoptosis by overexpressing Myc through stromal cell-derived factor- (SDF-) 1 signaling or cell-cell interaction (Figure 1) [56]. There are more than 900 scientific publications published related to "stem cell" and "autoimmune disease" on the. More well-designed and randomised controlled trials are needed to evaluate the best approach and universal consensus. There were no significant alterations in serum levels of alanine aminotransferase and creatinine (Figure (Figure33). Ranjbaran H, Abediankenari S, Khalilian A, Rahmani Z, Momeninezhad Amiri M, Hosseini Khah Z. Differentiation of Wharton's Jelly Derived Mesenchymal Stem Cells into Insulin Producing Cells. The application of MSCs in T2DM treatment exemplifies that NLRP3 formation was inhibited through immune response regulation of MSCs, thus enhancing the function of IRS-1 and GLUT4 in hepatic cells (Figure 2) [35]. Background. Specialty type: Endocrinology and metabolism, Peer-review reports scientific quality classification, P-Reviewer: Bayoumi RAL, United Arab Emirates; Salim A, Pakistan S-Editor: Zhang H L-Editor: A P-Editor: Zhang H. Xiao-Fen Lian, Department of Endocrinology, Peking University Shenzhen Hospital, Shenzhen 518000, Guangdong Province, China. The condition commonly affects the hips, knees, and thumbs, though it can also strike elbows, wrists, ankles, and fingers. Department of Endocrinology, Peking University Shenzhen Hospital, Shenzhen 518000, Guangdong Province, China, Department of Research & Development, Zhejiang MaiDa Gene Tech Co. Ltd, Zhoushan 316000, Zhejiang Province, China, Department of Endocrinology, Huizhou Central People's Hospital, Huizhou 516000, Guangdong Province, China, Department of Endocrinology, Longgang District Central Hospital of Shenzhen, Shenzhen 518000, Guangdong Province, China, Department of Endocrinology, Peking University Shenzhen Hospital, Shenzhen 518000, Guangdong Province, China. The MSC sources, animal models, delivery routes, and interventions used in these research studies have been summarized in Table 1. Generally, a longer time is needed to induce -cell dysfunction than insulin resistance and hyperlipidemia, while 30 weeks were taken to induce nonalcoholic steatohepatitis (NASH) syndrome in small animals [18]. moc.361@mfnyyzsxdjb. Within recent years, stem cell research has become a very important part of the scientific understanding of type 1 diabetes. Beta cell dysfunction and insulin resistance. Initially, the IR is compensated by increased insulin production; however, as the T2DM progresses over time, the general pancreatic dysfunction leads to increasingly lower insulin production. Get an overview of pipeline landscape @ Type 2 Diabetes Clinical Trials Analysis . Stem Cell Therapy Clinic, Mexico; Clinical Research . There are more than 3,000 publications related to the use of stem cells in diabetes mellitus. Caplan et al[28] demonstrated that MSCs could ameliorate -cell damage and restore islet -cell function in a murine model in the early stage (7 d) of MSC treatment. Careers. Furthermore, Deng et al. Shuang Gao, Yuanyuan Zhang, and Kaini Liang contributed equally to this work under the supervision of Yanan Du. Download scientific diagram | Confirm the up-regulation of CCR7 expression on T cells by the ex vivo studies. The high prevalence of erectile dysfunction (ED) in patients with type 2 diabetes mellitus (DM2) is a challenging clinical problem. proved that BM-MSCs could reduce islet cell apoptosis as decreased cleavage of caspase 3 in vivo was observed after MSC treatment [54]. However, further in-depth clarifications regarding the mechanisms of action of MSCs in treating T2DM are still a requisite. It did not recur after reducing the dosage of insulin in the following period. The dosages of oral hypoglycemic agents and insulin were adjusted according to the patient's blood glucose to keep the level stable, at FPG range of 79.2-126 mg/dL and P2PG range of 79.2-180 mg/dL. Here, we have listed and compiled all significant scientific publications related to stem cell therapy. . Yang Yang, Department of Endocrinology, Huizhou Central People's Hospital, Huizhou 516000, Guangdong Province, China. These dosages were adjusted by the treating physician according to standard clinical practice, based on blood glucose and A1c results. CRISPR/Cas9-based genetic correction for recessive dystrophic epidermolysis bullosa. [PMC free article] . CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement. government site. Liu X., Zheng P., Wang X., et al. In conclusion, the above mechanistic investigation provides a theoretical basis for the clinical application of MSCs in the treatment of T2DM along with its associated complications. The latest study confirmed that exosomal miR-29b-3p can regulate cellular insulin sensitivity via sirtuin- (SIRT-) 1 (Figure 2) [14], which is a class III histone deacetylase deeply involved in apoptosis, genomic stability, and gene expression regulation, indicating that histone modification related to insulin resistance is one of the treatment approaches of MSCs. Li M., al-Jamal K. T., Kostarelos K., Reineke J. Physiologically based pharmacokinetic modeling of nanoparticles. A-C: Leukocytes, hepatic and renal function; D-F: Antigen associated with tumor. Once its prepared, doctors inject it into the affected site, such as a knee joint. The https:// ensures that you are connecting to the Cardoso LMDF, Barreto T, Gama JFG, Alves LA. To evaluate the effectiveness and safety of human umbilical cord-mesenchymal stem cell (hUC-MSC) infusion in T2DM treatment. Bell et al[25] observed the expression of pancreatic and duodenal homeobox 1 and islet cell differentiation gradually increased after hUC-MSC treatment of streptozotocin-treated NOD-SCID mice. Despite the use of MSCs in clinical trials, many details still need to be discussed as their biodistribution varies under different treatment conditions. During the follow-up period, the participants performed self-monitoring of their fasting plasma glucose (FPG) and 2-h postprandial plasma glucose (P2PG) 7 times per week. Type 2 diabetes is usually diagnosed after age 45, however, it is being increasingly diagnosed in children and younger adults.

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